Right: list of cell populations isolated from six different fluorescent reporter mouse lines in four double-transgenic combinations.
W D GANN CYCLE PETER TAC SKIN
(A) Schematic of postnatal day (P)5 back skin with hair follicles (HF) from the three HF developmental waves. Using a systematic tissue-wide approach, this work provides a comprehensive platform, linked to an interactive online database, to identify and further explore the SC/TAC/niche crosstalk regulating HF growth.īig data dermal papilla epithelial-mesenchymal interactions hair follicle hair growth progenitors signaling networks stem cell niche stem cells systems biology transcriptomics.Ĭopyright © 2016 The Authors. Signaling interaction network analysis reveals a bird's-eye view of pathways implicated in epithelial-mesenchymal interactions. SC precursors, TACs, and the DP niche express a plethora of ligands and receptors. With next-generation RNA sequencing, we characterize their transcriptomes and define unique molecular signatures.
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Here we use six transgenic reporters to isolate 14 major skin and HF cell populations. Dermal papilla (DP) cells are required for SC activation during the adult hair cycle, but signal exchange between niche and SC precursors/transit-amplifying cell (TAC) progenitors that regulates HF morphogenetic growth is largely unknown. Electronic address: hair follicle (HF) is a complex miniorgan that serves as an ideal model system to study stem cell (SC) interactions with the niche during growth and regeneration.
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4 Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.3 Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.2 Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
![w d gann cycle peter tac w d gann cycle peter tac](https://images-na.ssl-images-amazon.com/images/I/41EaGQ3OGAL._AC_UL160_SR160,160_.jpg)
1 Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.